367-24-8
- Product Name：4-Bromo-2-fluoroaniline
- Molecular Formula：C6H5BrFN
- Purity：99%
- Molecular Weight：190.015
Product Details;
CasNo： 367-24-8
Molecular Formula： C6H5BrFN
Appearance： solid
factory and supplier 367-24-8 4-Bromo-2-fluoroaniline in stock
- Molecular Formula:C6H5BrFN
- Molecular Weight:190.015
- Appearance/Colour:solid
- Vapor Pressure:1.62mmHg at 25°C
- Melting Point:40-42 °C
- Refractive Index:1.52
- Boiling Point:210 °C at 760 mmHg
- PKA:2.50±0.10(Predicted)
- Flash Point:104.4 °C
- PSA：26.02000
- Density:1.694 g/cm3
- LogP:2.75160
4-Bromo-2-fluoroaniline(Cas 367-24-8) Usage
|
Synthesis |
To a stirred solution of 4-bromo-2-fluoro-l -nitrobenzene (10 g, 45.5 mmol) in EtOH (50 mL)AVater (20 mL) was added iron (12.7 g, 230 mmol) and NH4C1 (24.3 g, 455 mmol). The reaction mixture was stirred at 90 °C for 2 h. After 2 h the reaction mixture was filtered over Celite. The filter cake was washed with EtOH (300 mL), and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (S1O2, Petroleum ether/EtOAc=10: l to 5: 1) to afford 4-bromo-2-fluoroaniline. |
InChI:InChI:1S/C6H5BrFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
367-24-8 Relevant articles
A Practical Procedure for Regioselective Bromination of Anilines
Takahashi, Yusuke,Seki, Masahiko
, p. 1828 - 1832 (2021/04/15)
A highly practical procedure for the pre...
Aryl halide and synthesis method and application thereof
-
Paragraph 0058-0060, (2020/06/02)
The invention discloses a synthesis meth...
Visible-light-promoted oxidative halogenation of (hetero)arenes
Jiang, Xuefeng,Li, Yiming,Lu, Lingling
supporting information, p. 5989 - 5994 (2020/10/18)
Organic halides are critical building bl...
NOVEL SUBSTITUTED CYCLOBUTYLBENZENE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS
-
Page/Page column 78, (2019/05/02)
Disclosed herein is a compound of formul...
367-24-8 Process route
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-
321-23-3
4-bromo-2-fluoronitrobenzene
-
-
367-24-8
4-bromo-2-fluoroaniline
| Conditions | Yield |
|---|---|
|
With
tin(II) chloride dihdyrate;
In
ethyl acetate;
|
|
|
With
iron; acetic acid;
In
ethanol;
at 80 ℃;
for 1h;
|
|
|
With
iron; ammonium chloride;
In
ethanol; water;
at 90 ℃;
for 2h;
|
-
-
1601-98-5
1,2-bis(4-bromophenyl)diazene
-
-
367-24-8
4-bromo-2-fluoroaniline
| Conditions | Yield |
|---|---|
|
1,2-bis(4-bromophenyl)diazene;
With
N-fluorobis(benzenesulfon)imide; potassium nitrate; bis(dibenzylideneacetone)-palladium(0);
In
ethyl acetate;
at 90 ℃;
for 12h;
Sealed tube;
With
sodium tetrahydroborate; copper(l) chloride;
In
ethanol;
at 20 ℃;
for 0.166667h;
|
56.7 mg |
|
Multi-step reaction with 2 steps
1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 90 °C / Sealed tube
2: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
With
sodium tetrahydroborate; N-fluorobis(benzenesulfon)imide; potassium nitrate; copper(l) chloride; bis(dibenzylideneacetone)-palladium(0);
In
ethanol; ethyl acetate;
|
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-
106-40-1
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129367-47-1
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Relevant Products
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-
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-
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