2924-09-6
- Product Name：5-Bromo-2-fluoroaniline
- Molecular Formula：C6H5BrFN
- Purity：99%
- Molecular Weight：190.015
Product Details;
CasNo： 2924-09-6
Molecular Formula： C6H5BrFN
factory and supplier 2924-09-6 5-Bromo-2-fluoroaniline in stock
- Molecular Formula:C6H5BrFN
- Molecular Weight:190.015
- Vapor Pressure:0.0843mmHg at 25°C
- Melting Point:27℃
- Refractive Index:1.596
- Boiling Point:225.9 °C at 760 mmHg
- PKA:2.13±0.10(Predicted)
- Flash Point:90.4 °C
- PSA：26.02000
- Density:1.694 g/cm3
- LogP:2.75160
5-BROMO-2-FLUOROANILINE(Cas 2924-09-6) Usage
InChI:InChI=1/C6H5BrFN/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2
2924-09-6 Relevant articles
1,3-dibromo-4-fluorobenzene preparation method
-
Paragraph 0011; 0014, (2019/02/27)
The invention discloses an industrial pr...
Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination
Mao, Yang-Jie,Luo, Gen,Hao, Hong-Yan,Xu, Zhen-Yuan,Lou, Shao-Jie,Xu, Dan-Qian
supporting information, p. 14458 - 14461 (2019/12/09)
A detailed mechanism study on the anion ...
A 3-amino-4-fluorophenylboronic acid synthesis method
-
Paragraph 0022, (2016/11/24)
The invention discloses a synthetic meth...
Discovery of selective N-[3-(1-methyl-piperidine-4-carbonyl)-phenyl]-benzamide-based 5-HT1F receptor agonists: Evolution from bicyclic to monocyclic cores
Zhang, Deyi,Blanco, Maria-Jesus,Ying, Bai-Ping,Kohlman, Daniel,Liang, Sidney X.,Victor, Frantz,Chen, Qi,Krushinski, Joseph,Filla, Sandra A.,Hudziak, Kevin J.,Mathes, Brian M.,Cohen, Michael P.,Zacherl, Deanna,Nelson, David L.G.,Wainscott, David B.,Nutter, Suzanne E.,Gough, Wendy H.,Schaus, John M.,Xu, Yao-Chang
, p. 4337 - 4341 (2015/11/03)
Preclinical experiments and clinical obs...
2924-09-6 Process route
-
-
364-73-8
4-Bromo-1-fluoro-2-nitrobenzene
-
-
2924-09-6
5-bromo-2-fluoroaniline
| Conditions | Yield |
|---|---|
|
With
iron; ammonium chloride;
In
ethanol; water;
at 70 ℃;
for 24h;
|
91% |
|
With
water; iron;
at 90 ℃;
|
80% |
|
With
tin(II) chloride dihdyrate; ethanol;
for 1h;
Reflux;
|
71% |
|
With
iron; acetic acid;
at 105 ℃;
for 4h;
|
67% |
|
With
tin(ll) chloride;
In
ethanol;
Heating / reflux;
|
66% |
|
With
iron; acetic acid;
In
ethanol;
at 60 ℃;
Concentration;
Temperature;
|
62.5% |
|
With
iron; ammonium chloride;
In
water;
at 100 ℃;
for 6.25h;
|
53% |
|
With
ammonium chloride; iron;
In
water;
at 100 ℃;
for 5h;
|
53% |
|
With
tin(II) chloride dihdyrate;
In
ethanol;
for 4h;
Reflux;
|
46.5% |
|
With
iron;
|
|
|
With
Bechamp-suspension; iron; ammonium chloride;
Yield given. Multistep reaction;
1.) water, reflux, 30 min; 2.) reflux, 300 min;
|
|
|
With
iron; ammonium chloride;
for 48h;
Heating;
|
|
|
With
tin(ll) chloride;
In
ethanol;
at 20 ℃;
Product distribution / selectivity;
|
|
|
With
iron; ammonium chloride;
In
methanol; water;
at 80 ℃;
for 2h;
|
|
|
With
tin(ll) chloride;
In
ethanol;
at 20 - 60 ℃;
for 16h;
Product distribution / selectivity;
|
|
|
With
tin(II) chloride dihdyrate; ethanol;
for 4h;
Reflux;
|
-
-
364-73-8
4-Bromo-1-fluoro-2-nitrobenzene
-
-
348-54-9
2-Fluoroaniline
-
-
2924-09-6
5-bromo-2-fluoroaniline
| Conditions | Yield |
|---|---|
|
With
5%-palladium/activated carbon; hydrazine hydrate;
In
methanol;
at 80 ℃;
for 0.0833333h;
Overall yield = 37 %;
|
2924-09-6 Upstream products
-
364-73-8
4-Bromo-1-fluoro-2-nitrobenzene
-
364-76-1
4-Fluoro-3-nitroaniline
-
1493-27-2
ortho-nitrofluorobenzene
-
63213-03-6
1,2-bis(3-bromophenyl)diazene
2924-09-6 Downstream products
-
86156-96-9
4-amino-2-bromo-5-fluorobenzenesulfonic acid
-
214916-08-2
5-bromo-2-fluoro-phenylhydrazine hydrochloride
-
627871-08-3
(5-bromo-2-fluorophenyl)hydrazine
-
628692-06-8
4-bromo-N-(5-bromo-2-fluorophenyl)butyramide
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