348-54-9
- Product Name：2-Fluoroaniline
- Molecular Formula：C6H6FN
- Purity：99%
- Molecular Weight：111.119
Product Details;
CasNo： 348-54-9
Molecular Formula： C6H6FN
Appearance： Clear colorless to brown liquid
factory and supplier 348-54-9 2-Fluoroaniline in stock
- Molecular Formula:C6H6FN
- Molecular Weight:111.119
- Appearance/Colour:Clear colorless to brown liquid
- Vapor Pressure:1 hPa (20 °C)
- Melting Point:-29 °C
- Refractive Index:1.5420
- Boiling Point:182.499 °C at 760 mmHg
- PKA:3.2(at 25℃)
- Flash Point:60 °C
- PSA：26.02000
- Density:1.158 g/cm3
- LogP:1.98910
2-Fluoroaniline(Cas 348-54-9) Usage
|
Synthesis Reference(s) |
Tetrahedron Letters, 25, p. 3415, 1984 DOI: 10.1016/S0040-4039(01)91034-2 |
|
Air & Water Reactions |
Water soluble. |
|
Reactivity Profile |
2-Fluoroaniline is a base. Neutralizes acids to form salts plus water in an exothermic reaction. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. |
|
Health Hazard |
Inhalation or ingestion causes bluish tint to fingernails, lips and ears indicative of cyanosis; headache, drowsiness, and nausea, followed by unconsciousness. Liquid can be absorbed through skin and cause similar symptoms. Contact with eyes causes irritation. |
|
Fire Hazard |
Special Hazards of Combustion Products: Irritating and toxic hydrogen fluoride and oxides of nitrogen may form in fires. |
|
Metabolic pathway |
2-Fluoro and 3-fluoroanilines are preferentially hydroxylated at the para-position, and 4-fluoroaniline is both p- and o-hydroxylated to a significant extent by rat liver microsomes and is not accompanied with an NIH shift to give 4-hydroxyl-3-fluoroaniline. |
|
Application |
2-Fluoroaniline can be used to synthesize thermosensitive dye FH-102, which is a black thermosensitive dye with wide application and excellent performance. The dye can be used in the production of terminal output printing paper of electronic computer, EEG recording paper, telephone fax paper and transparent thermal film for oil field. |
|
Definition |
ChEBI: 2-fluoroaniline is a derivative of aniline in which the hydrogen at position 2 has been substituted by fluorine. It is used as a pharmaceutical intermediate It is a primary arylamine and a fluoroaniline. |
|
General Description |
Clear liquid with a mild sweet odor. Sinks in and mixes slowly with water. |
InChI:InChI=1/C6H6FN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
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348-54-9 Process route
-
-
1493-27-2,127723-77-7
ortho-nitrofluorobenzene
-
-
348-54-9
2-Fluoroaniline
-
-
367-25-9,76563-56-9
2,4-difluorophenylamine
| Conditions | Yield |
|---|---|
|
With
bismuth; hydrogen fluoride;
In
dichloromethane;
Yields of byproduct given;
|
65% |
-
-
462-06-6
fluorobenzene
-
-
372-19-0
meta-fluoroaniline
-
-
348-54-9
2-Fluoroaniline
-
-
371-40-4
4-fluoroaniline
| Conditions | Yield |
|---|---|
|
With
hydroxylamine-O-sulfonic acid;
iron(II) sulfate;
In
water; acetic acid;
at 40 ℃;
for 2h;
Yield given. Yields of byproduct given;
|
|
|
With
hydroxylamine-O-sulfonic acid;
iron(II) sulfate;
In
water; acetic acid;
at 40 ℃;
for 2h;
Product distribution;
Mechanism;
k(C6H5F)/k(C6H6);
|
|
|
With
sodium azide; boron trifluoride monohydrate;
at 55 ℃;
for 14h;
Overall yield = 48 %;
Sealed tube;
|
348-54-9 Upstream products
-
348-51-6
1-chloro-2-fluorobenzene
-
445-28-3
2-fluorobenzamide
-
446-23-1
N-chloro-2-fluorobenzamide
-
1493-27-2
ortho-nitrofluorobenzene
348-54-9 Downstream products
-
368-05-8
sym N,N′-di(2-fluorophenyl)thiourea
-
568-95-6
2-(2-fluorophenyl)isoindoline-1,3-dione
-
349-24-6
N-(2-Fluorophenyl)-2-hydroxyiminoacetamide
-
575-24-6
N-(2-fluorophenyl)-1-naphthylamine
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