452-84-6
- Product Name：2-Fluoro-5-methylaniline
- Molecular Formula：C7H8FN
- Purity：99%
- Molecular Weight：125.146
Product Details;
CasNo： 452-84-6
Molecular Formula： C7H8FN
Appearance： clear yellow to brown liquid
factory and supplier 452-84-6 2-Fluoro-5-methylaniline in stock
- Molecular Formula:C7H8FN
- Molecular Weight:125.146
- Appearance/Colour:clear yellow to brown liquid
- Vapor Pressure:0.307mmHg at 25°C
- Refractive Index:n20/D 1.533(lit.)
- Boiling Point:201.5 °C at 760 mmHg
- PKA:3.33±0.10(Predicted)
- Flash Point:81.7 °C
- PSA：26.02000
- Density:1.115 g/cm3
- LogP:2.29750
2-Fluoro-5-methylaniline(Cas 452-84-6) Usage
InChI:InChI=1/C7H8FN/c1-5-2-3-6(8)7(9)4-5/h2-4H,9H2,1H3
452-84-6 Relevant articles
-
Robertson
, p. 2051 (1959)
-
Synthesis of 2 - fluoro aniline compounds of the method
-
Paragraph 0092; 0093; 0095; 0096; 0097, (2019/05/15)
The invention discloses a method for syn...
Anion ligand promoted selective C-F bond reductive elimination enables C(sp2)-H fluorination
Mao, Yang-Jie,Luo, Gen,Hao, Hong-Yan,Xu, Zhen-Yuan,Lou, Shao-Jie,Xu, Dan-Qian
, p. 14458 - 14461 (2019/12/09)
A detailed mechanism study on the anion ...
An efficient method for aryl nitro reduction and cleavage of azo compounds using iron powder/calcium chloride
Chandrappa,Vinaya,Ramakrishnappa,Rangappa
experimental part, p. 3019 - 3022 (2011/03/17)
A novel, efficient Fe/CaCl2 system is re...
SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS INHIBITORS
-
, (2008/06/13)
The use of a compound of formula (I) 1 o...
452-84-6 Process route
-
-
588-04-5
3,3'-dimethylazobenzene
-
-
452-84-6
3-amino-4-fluorotoluene
| Conditions | Yield |
|---|---|
|
3,3'-dimethylazobenzene;
With
N-fluorobis(benzenesulfon)imide; potassium nitrate; bis(dibenzylideneacetone)-palladium(0);
In
dichloromethane;
at 55 ℃;
for 12h;
Sealed tube;
With
sodium tetrahydroborate; copper(l) chloride;
In
ethanol;
at 20 ℃;
for 0.166667h;
|
38.8 mg |
|
Multi-step reaction with 2 steps
1: bis(dibenzylideneacetone)-palladium(0); N-fluorobis(benzenesulfon)imide; potassium nitrate / ethyl acetate / 12 h / 55 °C / Sealed tube
2: sodium tetrahydroborate; copper(l) chloride / ethanol / 20 °C
With
sodium tetrahydroborate; N-fluorobis(benzenesulfon)imide; potassium nitrate; copper(l) chloride; bis(dibenzylideneacetone)-palladium(0);
In
ethanol; ethyl acetate;
|
-
-
446-11-7
4-fluoro-3-nitrotoluene
-
-
452-84-6
3-amino-4-fluorotoluene
| Conditions | Yield |
|---|---|
|
With
ethanol; iron; calcium chloride;
In
water;
at 60 ℃;
for 0.5h;
chemoselective reaction;
|
86% |
452-84-6 Upstream products
-
452-62-0
3-bromo-4-fluorotoluene
-
442-10-4
1-(2-fluoro-5-methyl-phenyl)-propan-1-one oxime
-
446-11-7
4-fluoro-3-nitrotoluene
-
588-04-5
3,3'-dimethylazobenzene
452-84-6 Downstream products
-
1513-25-3
2-chloro-1-fluoro-4-methylbenzene
-
7420-86-2
5-methyl-2-phenyl-1,3-benzoxazole
-
106976-08-3
2-(2-Fluoro-5-methyl-phenylamino)-3-nitro-benzoic acid
-
63762-79-8
2-fluoro-5-methylphenol
Relevant Products
-
1-Butyl-3-methylimidazolium tetrafluoroborateCAS：174501-65-6
-
1-Fluoro-2-iodobenzeneCAS：348-52-7
-
Di-tert-butylphosphineCAS：819-19-2
