30652-11-0
- Product Name：3-Hydroxy-1,2-dimethyl-4(1H)-pyridone
- Molecular Formula：C7H9NO2
- Purity：99%
- Molecular Weight：139.154
Product Details;
CasNo： 30652-11-0
Molecular Formula： C7H9NO2
Appearance： White needles
factory and supplier 30652-11-0 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone in stock
- Molecular Formula:C7H9NO2
- Molecular Weight:139.154
- Appearance/Colour:White needles
- Vapor Pressure:0.0107mmHg at 25°C
- Melting Point:272-275 °C(lit.)
- Refractive Index:1.564
- Boiling Point:232.7 °C at 760 mmHg
- PKA:pKa1 3.3, pKa2 9.7(at 25℃)
- Flash Point:94.5 °C
- PSA：42.23000
- Density:1.225 g/cm3
- LogP:0.39930
3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE(Cas 30652-11-0) Usage
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Drug interactions |
Potentially hazardous interactions with other drugsNone known. |
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Metabolism |
Deferiprone is hepatically metabolised to an inactive glucuronide metabolite and is excreted mainly in the urine as the metabolite and the iron-deferiprone complex, with a small amount of unchanged drug. |
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Definition |
ChEBI: A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. |
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Brand name |
Kelfer |
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General Description |
3-Hydroxy-1,2-dimethyl-4(1H)-pyridone (Hdpp, Deferiprone) is a hydroxy ketone derivative. It reacts with uranyl salts [UO2(NO3)2] in aqueous acidic solution to afford mono nuclear complexes ([UO2(dpp)(Hdpp)2(H2O)]ClO4). X-ray studies have been conducted to examine the structure and geometry of these complexes. |
InChI:InChI=1/C7H9NO2/c1-5-6(9)3-4-8(2)7(5)10/h3-4,10H,1-2H3
30652-11-0 Relevant articles
Dissociation of CP20 from iron(II)(cp20)3: A pulse radiolysis study
Merkofer, Martin,Domazou, Anastasia,Nauser, Thomas,Koppenol, Willem H.
, p. 671 - 675 (2006)
Deferiprone (CP20), a hydroxypyridine-4-...
Solid state properties of an oral iron chelator, 1,2-dimethyl-3-hydroxy-4-pyridone, and its acetic acid solvate. I: Physicochemical characterization, intrinsic dissolution rate, and solution thermodynamics
Chan,Venkataram,Grant,Rahman
, p. 677 - 685 (1991)
1,2-Dimethyl-3-hydroxy-4-pyridone (1), a...
Interaction between the low molecular mass components of blood serum and the VO(IV)-DHP system (DHP = 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone)
Buglyo, Peter,Kiss, Tamas,Kiss, Erzsebet,Sanna, Daniele,Garribba, Eugenio,Micera, Giovanni
, p. 2275 - 2282 (2002)
In order to estimate the impact of the l...
First insights into the novel class of organometallic compounds bearing a bidentate selenopyridone coordination motif: Synthesis, characterization, stability and biological investigations
Gajic, Natalie,Harringer, Sophia,Hejl, Michaela,Jakupec, Michael A.,Kandioller, Wolfgang,Keppler, Bernhard K.,Matzinger, Manuel
, (2020)
A series of seven piano–stool complexes ...
Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior
Gajic, Natalie,Happl, Barbara,Harringer, Sophia,Hejl, Michaela,Jakupec, Michael A.,Kandioller, Wolfgang,Kast, Caroline,Keppler, Bernhard K.,Koellensperger, Gunda,Legin, Anton A.,Ozenil, Marius,Roller, Alexander,Schweikert, Andreas,Wernitznig, Debora
, (2020/04/20)
A series of 16 dinuclear thiopyridone-ba...
Discovery of N-Aryl-pyridine-4-ones as Novel Potential Agrochemical Fungicides and Bactericides
Yu, Xiuqiang,Zhu, Xinyue,Zhou, Yang,Li, Qinglin,Hu, Zhan,Li, Ting,Tao, Jun,Dou, Menglan,Zhang, Meng,Shao, Yu,Sun, Ranfeng
, p. 13904 - 13913 (2019/12/24)
A series of N-aryl-pyridine-4-one deriva...
Application of 1-aryl-4-pyridone compound
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Paragraph 0071-0074, (2020/01/12)
The invention discloses application of a...
30652-11-0 Process route
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118-71-8
Maltol
-
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74-89-5
methylamine
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-
30652-11-0
deferiprone
| Conditions | Yield |
|---|---|
|
In
water;
for 10h;
Reflux;
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69% |
|
In
water;
at 160 - 162 ℃;
for 0.0216667h;
under 6750.5 Torr;
Irradiation;
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65% |
|
In
water;
for 6.5h;
Heating;
|
60% |
|
Heating;
|
54% |
|
With
hydrogenchloride;
for 5h;
Heating;
|
|
|
With
hydrogenchloride;
In
methanol; water;
Reflux;
Inert atmosphere;
|
|
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In
water;
at 75 - 90 ℃;
for 5.5h;
|
|
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In
water;
Reflux;
|
-
-
90037-22-2
1,2-dimethyl-3-(benzyloxy)-4(1H)-pyridinone
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-
30652-11-0
deferiprone
| Conditions | Yield |
|---|---|
|
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 2h;
|
80% |
|
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran;
under ambient conditions;
|
65% |
|
With
concentrated hydrobromic acid;
|
30652-11-0 Upstream products
-
118-71-8
Maltol
-
74-89-5
methylamine
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136003-98-0
3-Hydroxy-1,2-dimethyl-1H-pyridin-4-one; compound with acetic acid
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90037-22-2
1,2-dimethyl-3-(benzyloxy)-4(1H)-pyridinone
30652-11-0 Downstream products
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116629-47-1
(3-hydroxy-1,2-dimethyl-4-pyridinonato)diphenylboron
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146489-23-8
Pd(P(C6H5)3)2(C5H2NO2(CH3)2)(1+)*B(C6H5)4(1-)={Pd(P(C6H5)3)2(C5H2NO2(CH3)2)}B(C6H5)4
-
1219438-80-8
3-(2',3',4',6'-tetra-O-benzyl-β-D-glucopyranosyloxy)-1,2-dimethyl-4(1H)-pyridinone
-
1325206-85-6
1,2-dimethyl-3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)pyridin-4(1H)-one
Relevant Products
-
2,5-Dimethoxy-Beta-NitrostyreneCAS：40276-11-7
-
3,3'-BithiopheneCAS：3172-56-3
-
2-Chlorobenzoic acidCAS：118-91-2
