70-34-8
- Product Name：2,4-Dinitrofluorobenzene
- Molecular Formula：C6H3FN2O4
- Purity：99%
- Molecular Weight：186.099
Product Details;
CasNo： 70-34-8
Molecular Formula： C6H3FN2O4
Appearance： Yellow solid
factory and supplier 70-34-8 2,4-Dinitrofluorobenzene in stock
- Molecular Formula:C6H3FN2O4
- Molecular Weight:186.099
- Appearance/Colour:Yellow solid
- Vapor Pressure:0.000207mmHg at 25°C
- Melting Point:25-27 °C(lit.)
- Refractive Index:n20/D 1.569(lit.)
- Boiling Point:337.3 °C at 760 mmHg
- Flash Point:157.8 °C
- PSA：91.64000
- Density:1.586 g/cm3
- LogP:2.68850
2,4-Dinitrofluorobenzene(Cas 70-34-8) Usage
|
Air & Water Reactions |
Slightly soluble in water. |
|
Reactivity Profile |
Reacts with oxidizing agents . When air was admitted after vacuum evaporation of an ether peroxide solution, a violent explosion occurred. A halogenated aromatic nitro compound. Aromatic nitro compounds range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. |
|
Fire Hazard |
2,4-Dinitrofluorobenzene is probably combustible. |
|
Contact allergens |
DNFB is a strong skin irritant and a universal contact allergen. It is used as an intermediate in the synthesis of pesticides and pharmaceuticals such as flurbiprofen, a chemical reagent, and as a topical sensitizer for the treatment of alopecia areata |
|
Biochem/physiol Actions |
1-Fluoro-2,4-dinitrobenzene is a contact-sensitizing hapten, commonly used in experimental studies on contact hypersensitivity, inducing itch model, and atopic dermatitis. Mast cell activation is a key step in the DNFB induced sensitivity. DNFB covalently binds to the N-terminal amino acid of the protein and aids in Sanger sequencing. |
|
Safety Profile |
Poison by ingestion,skin contact, and subcutaneous routes. A powerful irritant and vesicant. Mutation data reported. Solutions in ether may explode when evaporated* When heated to decomposition it emits highly toxic fumes of NOx and F-. See also NITRO E COMPOUNDS of AROMATIC HYDROCARBONS and FLUORIDES. |
|
Purification Methods |
Crystallise the reagent from Et2O or EtOH. Distil it in a vacuum through a Todd Column (p 11). If it is to be purified by distillation in vacuo, the distillation unit must be allowed to cool before air is allowed into the apparatus; otherwise the residue carbonises spontaneously and an EXPLOSION may occur. The material is a skin irritant and may cause serious dermatitis. [Beilstein 5 IV 742.] |
|
Definition |
ChEBI: The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions. |
|
General Description |
Clear yellow crystals or yellow crystalline solid. |
InChI:InChI=1/C6H3FN2O4/c7-4-2-1-3-5(8(10)11)6(4)9(12)13/h1-3H
70-34-8 Relevant articles
FORMATION OF FLUORO-MEISENHEIMER COMPLEXES USING HOMOGENEOUS AND HETEROGENEOUS FLUORIDE ION SOURCES
Clark, J. H.,Robertson, M. S.,Smith, D. K.,Cook, A.,Streich, C.
, p. 161 - 170 (1985)
1-Chloro-2,4-dinitrobenzene, 1-fluoro-2,...
Reactions at solid-liquid interfaces. The mechanism and kinetics of the fluorination of 2,4-dinitrochlorobenzene using solid potassium fluoride in dimethylformamide
Macfie, Gavin,Brookes, Benjamin A.,Compton, Richard G.
, p. 12534 - 12546 (2001)
The halogen exchange reaction of 2,4-dic...
CATALYTIC EFFECT OF DICYCLOHEXYL-18-CROWN-6-ETHER STEREOISOMERS IN THE SUBSTITUTION REACTIONS OF AROMATICALLY BOUND CHLORINE BY FLUORINE
Aksenov, V. V.,Vlasov, V. M.,Moryakina, I. M.,Rodionov, P. P.,Fadeeva, V. P.
, p. 629 - 630 (1987)
-
HALOGEN-EXCHANGE FLUORINATION OF AROMATIC HALIDES USING HF OR HF-BASE SOLUTIONS
Yoneda, N.,Fukuhara, T.,Hatta, M.,Suzuki, A.
, p. 161 (1991)
-
Process for fluorinating inorganic or organic compounds by direct fluorination
-
Paragraph 0326-0330, (2020/07/14)
The invention relates to the use of a fl...
A rings-in-pores net: Crown ether-based covalent organic frameworks for phase-transfer catalysis
Guo, Wen-Di,Hu, Bingwen,Jiang, Wei-Ling,Lou, Xiaobing,Ma, De-Li,Qi, Qiao-Yan,Shen, Ji-Chuang,Shen, Ming,Yang, Hai-Bo,Zhao, Xin
supporting information, p. 595 - 598 (2020/01/29)
We herein present a new family of crown ...
Preparation and characterization of a novel silica-KF composite and facile fluorination of aromatic substrates
Patel, Sagar S.,Bochare, Machhindra D.,Degani, Mariam S.
, p. 20095 - 20100 (2018/12/13)
A novel silica-KF reagent prepared by hy...
Regioselective dinitration of simple aromatics over zeolite Hβ/nitric acid/acid anhydride systems
Smith, Keith,Alotaibi, Mohammad Hayal,El-Hiti, Gamal A.
, p. 107 - 123 (2014/04/17)
Various nitration systems comprising nit...
70-34-8 Process route
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-
950487-33-9
3-(2,4-dinitrophenoxy)-3-fluoro-3H-diazirine
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-
51-28-5
2,4-Dinitrophenol
-
-
70-34-8,65727-75-5
2,4-Dinitrofluorobenzene
-
-
693-85-6
3,3-difluoro-3H-diazirine
-
-
diazacyclopropenone
| Conditions | Yield |
|---|---|
|
With
N,N,N,N,N,N-hexamethylphosphoric triamide; 15-crown-5; lithium fluoride;
In
N,N,N,N,N,N-hexamethylphosphoric triamide;
at 55 ℃;
under 1 Torr;
Molecular sieve;
Cooling with liquid nitrogen;
|
|
|
With
potassium fluoride;
In
N,N,N,N,N,N-hexamethylphosphoric triamide;
at 55 ℃;
under 1 Torr;
Molecular sieve;
Cooling with liquid nitrogen;
|
-
-
97-00-7
1-chloro-2,4-dinitro-benzene
-
-
51-28-5
2,4-Dinitrophenol
-
-
70-34-8,65727-75-5
2,4-Dinitrofluorobenzene
| Conditions | Yield |
|---|---|
|
With
[2,2]bipyridinyl; copper (II)-fluoride;
In
acetonitrile;
at 82 ℃;
for 5h;
Title compound not separated from byproducts;
|
25 % Chromat. 39 % Chromat. |
70-34-8 Upstream products
-
462-06-6
fluorobenzene
-
350-46-9
4-Fluoronitrobenzene
-
97-00-7
1-chloro-2,4-dinitro-benzene
-
584-48-5
2,4-dinitrobromobenzene
70-34-8 Downstream products
-
839-93-0
1-(2,4-dinitrophenyl)piperidine
-
7061-92-9
1,4-bis(2,4-dinitrophenyl)piperazine
-
14545-01-8
N-2,4-dinitrophenylimidazole
-
124135-61-1
1,8-bis-(2,4-dinitro-phenyl)-1,8-diaza-cyclotetradecane
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