1651-29-2
- Product Name：6-Chloro-2-fluoropurine
- Molecular Formula：C5H2ClFN4
- Purity：99%
- Molecular Weight：172.549
Product Details;
CasNo： 1651-29-2
Molecular Formula： C5H2ClFN4
Appearance： almost white crystalline powder
factory and supplier 1651-29-2 6-Chloro-2-fluoropurine in stock
- Molecular Formula:C5H2ClFN4
- Molecular Weight:172.549
- Appearance/Colour:almost white crystalline powder
- Vapor Pressure:0.101mmHg at 25°C
- Melting Point:162-163 °C
- Refractive Index:1.304
- Boiling Point:553.2 °C at 760 mmHg
- PKA:4.88±0.20(Predicted)
- Flash Point:288.4 °C
- PSA：54.46000
- Density:1.766 g/cm3
- LogP:1.14540
6-Chloro-2-fluoropurine(Cas 1651-29-2) Usage
InChI:InChI=1/C11H7F17O/c12-4(13,2-1-3-29)5(14,15)6(16,17)7(18,19)8(20,21)9(22,23)10(24,25)11(26,27)28/h29H,1-3H2
1651-29-2 Relevant articles
N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors
Casalvieri, Kimberly A.,Matheson, Christopher J.,Warfield, Becka M.,Backos, Donald S.,Reigan, Philip
supporting information, (2021/06/02)
The RSK2 kinase is the downstream effect...
Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation
Calzaferri, Francesco,Narros-Fernández, Paloma,De Pascual, Ricardo,De Diego, Antonio M.G.,Nicke, Annette,Egea, Javier,García, Antonio G.,De Los Ríos, Cristóbal
, p. 2272 - 2290 (2021/03/01)
The ATP-gated P2X7 purinergic receptor (...
2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase
Bayliss, Richard,Boxall, Kathy,Carbain, Benoit,Coxon, Christopher R.,Fry, Andrew M.,Golding, Bernard T.,Griffin, Roger J.,Hardcastle, Ian R.,Harnor, Suzannah J.,Mas-Droux, Corine,Matheson, Christopher J.,Newell, David R.,Richards, Mark W.,Sivaprakasam, Mangaleswaran,Turner, David,Cano, Céline
, p. 707 - 731 (2020/08/24)
Renewed interest in covalent inhibitors ...
Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines
Coxon, Christopher R.,Anscombe, Elizabeth,Harnor, Suzannah J.,Martin, Mathew P.,Carbain, Benoit,Golding, Bernard T.,Hardcastle, Ian R.,Harlow, Lisa K.,Korolchuk, Svitlana,Matheson, Christopher J.,Newell, David R.,Noble, Martin E. M.,Sivaprakasam, Mangaleswaran,Tudhope, Susan J.,Turner, David M.,Wang, Lan Z.,Wedge, Stephen R.,Wong, Christopher,Griffin, Roger J.,Endicott, Jane A.,Cano, Céline
, p. 1746 - 1767 (2017/03/17)
Purines and related heterocycles substit...
1651-29-2 Process route
-
-
10310-21-1
2-Amino-6-chloropurin
-
-
1651-29-2
6-chloro-2-fluoropurine
| Conditions | Yield |
|---|---|
|
With
tetrafluoroboric acid; sodium nitrite;
at -10 - 0 ℃;
for 0.5h;
|
89% |
|
With
tetrafluoroboric acid; sodium nitrite;
In
water;
at 0 - 20 ℃;
for 0.75h;
|
82% |
|
2-Amino-6-chloropurin;
With
tetrafluoroboric acid;
In
water;
at 0 ℃;
for 0.333333h;
With
sodium nitrite;
In
water;
at 0 - 20 ℃;
|
75% |
|
With
sodium nitrite;
In
water;
-15 deg C, 75 min, r.t., 20 min;
|
61% |
|
With
sodium nitrite;
In
HBF4; dichloromethane; water;
|
49.1% |
|
2-Amino-6-chloropurin;
With
fluoroboric acid; sodium nitrite;
In
water;
at -15 - 20 ℃;
for 1.75h;
With
sodium hydroxide;
In
water;
at -15 ℃;
pH=6.2;
|
48% |
|
With
tetrafluoroboric acid; sodium nitrite;
In
water;
at -15 - 20 ℃;
for 1.75h;
|
48% |
|
With
tetrafluoroboric acid; sodium nitrite;
|
|
|
With
pyridine; tert.-butylnitrite; hydrogen fluoride;
In
pyridine;
at -60 - -50 ℃;
for 0.666667h;
|
-
-
C10H10ClN5O3
-
-
1651-29-2
6-chloro-2-fluoro-7H-purine
| Conditions | Yield |
|---|---|
|
With
ammonium fluoride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 10h;
|
83% |
1651-29-2 Upstream products
-
10310-21-1
2-Amino-6-chloropurin
-
10310-21-1
2-amino-6-chloropurine
-
7306-68-5
6-chloro-9-(tetrahydro-2H-pyran-2-yl)-9H-purine
1651-29-2 Downstream products
-
141684-89-1
9-[(2S,3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-phenylselanyl-tetrahydro-furan-2-yl]-6-chloro-2-fluoro-9H-purine
-
141684-89-1
6-chloro-2-fluoro-9-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-2-Se-phenyl-2-seleno-β-D-erythro-pentofuranosyl>-9H-purine
-
188644-29-3
2-fluoro-N-(4-nitrobenzyl)-9H-purin-6-amine
-
101622-51-9
olomoucine
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