1195768-18-3
- Product Name：Methyl 3-amino-2-fluorobenzoate
- Molecular Formula：C8H8FNO2
- Purity：99%
- Molecular Weight：169.155
Product Details;
CasNo： 1195768-18-3
Molecular Formula： C8H8FNO2
factory and supplier 1195768-18-3 Methyl 3-amino-2-fluorobenzoate in stock
- Molecular Formula:C8H8FNO2
- Molecular Weight:169.155
- Refractive Index:1.5570 to 1.5610
- Boiling Point:295.978 °C at 760 mmHg
- PKA:2.06±0.10(Predicted)
- Flash Point:132.803 °C
- PSA：52.32000
- Density:1.219 g/cm3
- LogP:1.77570
1195768-18-3 Relevant articles
From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (MKK4)
Kl?vekorn, Philip,Pfaffenrot, Bent,Juchum, Michael,Selig, Roland,Albrecht, Wolfgang,Zender, Lars,Laufer, Stefan A.
supporting information, (2020/11/20)
The mitogen-activated protein kinase (MA...
ALTERNATE PROCESSES FOR THE PREPARATION OF OMECAMTIV MECARBIL
-
, (2021/04/17)
Aspects of the present application relat...
Synthesis method of anti-cancer drug intermediate methyl 2-fluoro-3-aminobenzoate
-
Paragraph 0052-0055, (2020/07/13)
The invention discloses a synthetic meth...
PROTEIN KINASE INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH
-
Page/Page column 32; 53, (2018/08/12)
The invention relates to MKK4 (mitogen-a...
1195768-18-3 Process route
-
-
946126-94-9
2-fluoro-3-nitrobenzoic acid methyl ester
-
-
1195768-18-3
3-amino-2-fluorobenzoic acid methyl ester
| Conditions | Yield |
|---|---|
|
With
palladium 10% on activated carbon; hydrogen;
In
ethanol;
|
99% |
|
With
palladium 10% on activated carbon; hydrogen;
In
ethyl acetate;
at 20 ℃;
Solvent;
Reagent/catalyst;
|
97% |
|
With
ammonium chloride; zinc;
In
methanol;
at 0 - 20 ℃;
for 1.16667h;
|
92% |
|
With
hydrazine hydrate;
In
tetrahydrofuran; methanol;
at 70 ℃;
Inert atmosphere;
|
68% |
|
With
hydrazine hydrate;
nickel;
In
tetrahydrofuran; methanol; water;
at 70 ℃;
|
68% |
|
With
iron; acetic acid;
In
ethanol;
for 2h;
Reflux;
|
|
|
With
iron; acetic acid;
In
ethanol;
for 2h;
Reflux;
|
|
|
With
palladium on activated charcoal; hydrogen;
In
tetrahydrofuran;
at 50 - 60 ℃;
for 24h;
under 2250.23 - 7500.75 Torr;
|
70 mg |
-
-
206551-41-9
2-fluoro-3-bromobenzoic acid methyl ester
-
-
1195768-18-3
3-amino-2-fluorobenzoic acid methyl ester
| Conditions | Yield |
|---|---|
|
2-fluoro-3-bromobenzoic acid methyl ester;
With
tert-butyl carbazate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
toluene;
at 90 ℃;
Inert atmosphere;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
|
76% |
|
Multi-step reaction with 2 steps
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid;
In
dichloromethane;
|
|
|
Multi-step reaction with 2 steps
1: caesium carbonate / tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 90 °C / Inert atmosphere
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
With
caesium carbonate; trifluoroacetic acid;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
dichloromethane; toluene;
|
1195768-18-3 Upstream products
-
946126-94-9
2-fluoro-3-nitrobenzoic acid methyl ester
-
1042055-86-6
methyl 3-((tert-butoxycarbonyl)amino)-2-fluorobenzoate
-
317-46-4
2-fluoro-3-nitro-benzoic acid
-
161957-56-8
3-bromo-2-fluorobenzoic acid
1195768-18-3 Downstream products
-
1195768-24-1
3-(2,5-Difluorobenzenesulfonylamino)-2-fluorobenzoic acid methyl ester
-
1195768-26-3
methyl-3-[(allyloxy)carbonyl]amino-2-fluorobenzoate
-
1195768-19-4
3-(2,6-difluorobenzenesulfonamido)-2-fluorobenzoic acid methyl ester
-
1315305-53-3
methyl 2-fluoro-3-(2-fluoro-3-nitrobenzamido)benzoate
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