18720-35-9
- Product Name：4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid
- Molecular Formula：C11H16O4
- Purity：99%
- Molecular Weight：212.246
Product Details;
CasNo： 18720-35-9
Molecular Formula： C11H16O4
factory and supplier 18720-35-9 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid in stock
- Molecular Formula:C11H16O4
- Molecular Weight:212.246
- Vapor Pressure:0mmHg at 25°C
- Melting Point:186.0 to 190.0 °C
- Refractive Index:1.551
- Boiling Point:322.473 °C at 760 mmHg
- PKA:4.77±0.10(Predicted)
- Flash Point:122.436 °C
- PSA：63.60000
- Density:1.307 g/cm3
- LogP:1.58460
BICYCLO[2.2.2]OCTANE-1,4-DICARBOXYLIC ACID HEMIMETHYL ESTER(Cas 18720-35-9) Usage
InChI:InChI=1/C11H16O4/c1-15-9(14)11-5-2-10(3-6-11,4-7-11)8(12)13/h2-7H2,1H3,(H,12,13)
18720-35-9 Relevant articles
Bicyclo [2.2.2] octane - 1, 4 - dicarboxylic acid mono methyl ester synthesis method
-
Paragraph 0007; 0024; 0025; 0026; 0027; 0036; 0037, (2017/07/07)
The invention relates to a synthetic met...
POLYMERIZABLE COMPOUND AND OPTICAL ANISOTROPIC BODY
-
Paragraph 0202-0204, (2018/01/02)
PROBLEM TO BE SOLVED: To provide a polym...
Substituted pyrazolo-piperazines as casein kinase 1 δ/ε inhibitors
-
Page/Page column 527; 528, (2016/03/19)
The invention provides compounds of Form...
Design and synthesis of novel 19F-amino acid: A promising 19F NMR label for peptide studies
Bandak, Dmytro,Babii, Oleg,Vasiuta, Roman,Komarov, Igor V.,Mykhailiuk, Pavel K.
supporting information, p. 226 - 229 (2015/03/05)
Novel aliphatic 19F-substituted amino ac...
18720-35-9 Process route
-
![dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate](/upload/2025/12/ac99ddfd-d210-49cf-865c-fef0bccb27bd.png)
-
1459-96-7
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
-
![1,4-bicyclo[2.2.2]octanedicarboxylic acid](/upload/2025/12/dafdf2c1-926c-4660-9602-6bbef3a2494f.png)
-
711-02-4
1,4-bicyclo[2.2.2]octanedicarboxylic acid
-
![bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester](/upload/2025/12/672c5b3e-df37-4e8a-9cb8-0ef4e6da7258.png)
-
18720-35-9
bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester
| Conditions | Yield |
|---|---|
|
With
barium dihydroxide;
In
methanol; water;
for 18h;
Ambient temperature;
|
-
-
1459-96-7
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate
-
-
18720-35-9
bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester
| Conditions | Yield |
|---|---|
|
With
potassium hydroxide;
In
methanol; water;
at 90 ℃;
|
95% |
|
With
potassium hydroxide; water;
In
methanol;
at -78 - -20 ℃;
for 3.75h;
Heating / reflux;
|
70% |
|
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;
With
potassium hydroxide; water;
In
methanol;
Heating / reflux;
With
hydrogenchloride;
In
water;
pH=1 - 2;
|
70% |
|
With
water; sodium hydroxide;
In
methanol;
at 20 - 75 ℃;
for 16h;
|
58% |
|
With
barium hydroxide octahydrate;
In
methanol; water;
at 20 ℃;
|
56% |
|
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;
With
water; potassium hydroxide;
In
methanol;
for 24h;
Reflux;
With
hydrogenchloride;
In
water;
pH=3;
|
55% |
|
With
water; sodium hydroxide;
In
methanol;
at 0 - 22 ℃;
for 72h;
|
55% |
|
With
potassium hydroxide;
In
methanol; water;
at 50 ℃;
for 24h;
|
50% |
|
With
potassium hydroxide;
In
methanol; water;
for 24h;
|
44.9% |
|
With
potassium hydroxide;
|
|
|
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;
With
barium hydroxide;
In
methanol; water;
at 20 - 25 ℃;
for 18h;
With
hydrogenchloride;
In
methanol; hexane; water;
pH=1 - 2;
|
|
|
dimethyl bicyclo[2.2.2]octane-1,4-dicarboxylate;
With
water; potassium hydroxide;
In
methanol;
for 24.5h;
Reflux;
With
hydrogenchloride;
In
water;
pH=~ 3;
|
|
|
With
methanol; sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 15.5h;
|
120.4 g |
|
With
barium(II) hydroxide;
In
methanol; water;
at 20 ℃;
for 12h;
|
|
|
With
lithium hydroxide;
In
methanol; water;
at 20 - 65 ℃;
for 6h;
|
|
|
With
potassium hydroxide;
In
methanol; water;
for 5h;
Reflux;
|
|
|
With
sodium hydroxide;
In
methanol;
at 50 ℃;
for 5h;
|
5.6 g |
18720-35-9 Upstream products
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-
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-
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-
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dimethyl 1,4-dioxobicyclo<2.2.2>octane-2,5-dicarboxylate
18720-35-9 Downstream products
-
94994-15-7
4-hydroxymethyl-bicyclo[2.2.2]octane-1-carboxylic acid methyl ester
-
862501-91-5
methyl 4-(((benzyloxy)carbonyl)amino)bicyclo[2.2.2]octane-1-carboxylate
-
96102-85-1
4-formyl-bicyclo[2.2.2]octane-1-carboxylic acid
-
959958-69-1
3-(4-(6-amino-2,4-dioxo-1-propyl-3-heptadeuteriopropyl-1,2,3,4-tetrahydro-pyrimidin-5-ylcarbamoyl)-bicyclo[2.2.2]oct-1-yl)propionic acid methyl ester
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