What is the CAS number for Dicyclohexylchlorophosphine?

The CAS number of Dicyclohexylchlorophosphine is 16523-54-9.

What is Dicyclohexylchlorophosphine (16523-54-9) used for?

Dicyclohexylchlorophosphine, also known as Chlorodicyclohexylphosphine, is a clear colorless liquid that serves as a versatile chemical intermediate and reactant in the synthesis of various phosphines and ligands. It is widely utilized in the pharmaceutical industry and in Pd-catalyzed cross-coupling reactions.InChI:InChI=1/C12H22ClP/c13-14(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h11-12H,1-10H2

What is the CAS number for Dicyclohexylchlorophosphine?

The CAS number of Dicyclohexylchlorophosphine is 16523-54-9.

What is Dicyclohexylchlorophosphine (16523-54-9) used for?

Dicyclohexylchlorophosphine, also known as Chlorodicyclohexylphosphine, is a clear colorless liquid that serves as a versatile chemical intermediate and reactant in the synthesis of various phosphines and ligands. It is widely utilized in the pharmaceutical industry and in Pd-catalyzed cross-coupling reactions.InChI:InChI=1/C12H22ClP/c13-14(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h11-12H,1-10H2

Product classification

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16523-54-9

Q: What is the Dicyclohexylchlorophosphine?

Dicyclohexylchlorophosphine is clear colorless liquid, while it's Molecular Formula is C12H22ClP. clear colorless liquid Chlorodicyclohexylphosphine can be used as a reactant in the synthesis of: 1,2-Bis(dicyclohexylphosphinoxy)ethane ligand by reacting with ethylene glycol in the presence of triethylamine via Michaelis?Arbuzov type rearrangements.1,1,2,2-tetracyclohexyldiphosphine monosulfide ligand by treating with LiS.It can be also used as a starting material for the preparation of some other ligands such as dicyclohexylphosphine oxide , phosphino substituted N-aryl pyrroles , di-tert-butyl((dicyclohexylphosphino)methyl)phosphine , dicyclohexylcyclopentylphosphine. These ligands are used in Pd-catalyzed cross-coupling reactions.

Product Name：Dicyclohexylchlorophosphine
Molecular Formula：C₁₂H₂₂ClP
Purity：99%
Molecular Weight：232.733

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Product Details;

CasNo： 16523-54-9

Molecular Formula： C₁₂H₂₂ClP

Appearance： clear colorless liquid

factory and supplier 16523-54-9 Dicyclohexylchlorophosphine in stock

Molecular Formula:C12H22ClP
Molecular Weight:232.733
Appearance/Colour:clear colorless liquid
Vapor Pressure:0.00238mmHg at 25°C
Melting Point:126-128 °C
Refractive Index:n20/D 1.533(lit.)
Boiling Point:297.5 °C at 760 mmHg
Flash Point:133.7 °C
PSA：13.59000
Density:1.054g/mLat 25°C(lit.)
LogP:5.28750

Dicyclohexylchlorophosphine(Cas 16523-54-9) Usage

Precautions

Store in cool, dry conditions in well sealed containers. Protect from humidity and water. Store under dry inert gas. It is sensitive to air and moisture. Incompatible with strong oxidizing agents.

Application

Chlorodicyclohexylphosphine can be used as a reactant in the synthesis of:1,2-Bis(dicyclohexylphosphinoxy)ethane ligand by reacting with ethylene glycol in the presence of triethylamine via Michaelis?Arbuzov type rearrangements.1,1,2,2-tetracyclohexyldiphosphine monosulfide ligand by treating with LiS.It can be also used as a starting material for the preparation of some other ligands such as dicyclohexylphosphine oxide , phosphino substituted N-aryl pyrroles , di-tert-butyl((dicyclohexylphosphino)methyl)phosphine , dicyclohexylcyclopentylphosphine. These ligands are used in Pd-catalyzed cross-coupling reactions.

InChI:InChI=1/C12H22ClP/c13-14(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h11-12H,1-10H2

16523-54-9 Relevant articles

The Use of Catalytic Amounts of CuCl and Other Improvements in the Benzyne Route to Biphenyl-Based Phosphine Ligands

Kaye, Steven,Fox, Joseph M.,Hicks, Frederick A.,Buchwald, Stephen L.

, p. 789 - 794 (2001)

Biphenyl-based phosphine ligands can be ...

DIALKYL(2-ALKOXY-6-AMINOPHENYL)PHOSPHINE, THE PREPARATION METHOD AND USE THEREOF

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Paragraph 0033; 0034, (2014/10/29)

The present invention relates to the com...

Zheda-phos for general α-monoarylation of acetone with aryl chlorides

Li, Pengbin,Lue, Bo,Fu, Chunling,Ma, Shengming

supporting information, p. 1255 - 1259 (2013/06/27)

A new, readily available, and air-stable...

STRUCTURE AND METHOD FOR SYNTHESIZING AND USING DIALKYL(2,4,6- OR 2,6-ALKOXYPHENYL)PHOSPHINE AND ITS TETRAFLUOROBORATE

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Page/Page column 4-5, (2012/08/08)

The current invention relates to the str...

2,6-diisopropoxyphenyl(dicyclohexyl)phosphine: A new ligand for palladium-catalyzed amination reactions of aryl chlorides with potassium hydroxide as the base

Lue, Bo,Li, Pengbin,Fu, Chunling,Xue, Liqin,Lin, Zhenyang,Ma, Shengming

experimental part, p. 100 - 112 (2011/04/12)

A new, readily available monophosphine t...

16523-54-9 Process route

: 829-84-5
dicyclohexylphosphane

: 16523-54-9
chlorodicyclohexylphosphane

Conditions

Conditions	Yield
With Ethyl trichloroacetate; In chlorobenzene; at 80 ℃; for 2.46667h; Product distribution / selectivity;	80.6%

: 931-51-1
cyclohexylmagnesiumchloride

: 16523-54-9
chlorodicyclohexylphosphane

Conditions

Conditions	Yield
With phosphorus trichloride;
With phosphorus trichloride; In diethyl ether;
With phosphorus trichloride; In toluene; at 0 ℃;
With phosphorus trichloride; In diethyl ether; at -40 - 20 ℃;
Multi-step reaction with 3 steps 2: HCl With hydrogenchloride;
With phosphorus trichloride; In diethyl ether; at -40 - 30 ℃;
With phosphorus trichloride; In diethyl ether; at -40 - 20 ℃; Product distribution / selectivity;
With phosphorus trichloride; In tetrahydrofuran; at -40 - 20 ℃; for 7h;