1522-22-1

Purification Methods

It forms a dihydrate which has no UV spectrum compared with max (CHCl3) 273nm ( 7,800) for the anhydrous ketone. The dihydrate decomposes at ~90o. The hydrate (10g) plus anhydous CaSO4 (Drierite, 30g) are heated and distilled, the distillate is treated with more CaSO4 and redistilled. When the distillate is treated with aqueous NaOH and heated, the dihydrate crystallises on cooling. The Cu complex has m 135o (after sublimation). [Gilman et al. J Am Chem Soc 78 2790 1956, Belford et al. J Inorg Nucl Chem 2 11 1956, Beilstein 1 IV 3681.]

General Description

**HEXAFLUOROACETYLACETONE (HFA)** is a fluorinated β-diketone commonly used as a ligand in coordination chemistry, particularly in the synthesis of metal complexes such as manganese(II) and cobalt(II) compounds. It serves as a chelating agent due to its ability to form stable complexes with transition metals, often contributing to the magnetic or cytotoxic properties of the resulting compounds. In the context of the provided literature, HFA is utilized in the preparation of antiferromagnetic manganese(II) complexes and cytotoxic cobalt(II) β-ketoaminato complexes, demonstrating its versatility in both materials science and medicinal chemistry applications.